Addressing Hypoglycemia and Hyperglycemia

Cardiovascular Importance of Hyperglycemia and Hypoglycemia

For addressing the question of cardiovascular importance of hypoglycemia, it is important to clarify its context. First, hypoglycemia is a result of treatment of hyperglycemia by oral insulin secretagogues or insulin. Chronic hyperglycemia usually expressed by HbA1c level is considered a risk factor for cardiovascular disease, although this epidemiological association does not necessarily mean ...

Effect of insulin hypoglycemia on alimentary hyperglycemia.

Insulin action is generally associated with an acceleration of glucose assimilation. If, for instance, a healthy person in the postabsorptive state is given glucose and simultaneously receives a small intravenous dose (from 3 to 5 units) of insulin, the resulting blood sugar time curve (glucose tolerance curve) is much flatter than one obtained upon feeding the same amount of glucose but withou...

First do no harm ... hypoglycemia or hyperglycemia?

Hypoglycemia and hyperglycemia in extremely low-birth-weight infants

Materials and methods All inborn ELBW neonates admitted to our NICU during a 5-year period were eligible for this retrospective analysis. Exclusion criteria were: birth weight (BW) <400 grams, major congenital malformations, death during the first 24 hours of life. Hypoglycemia was defined as blood glucose level (BGL) ≤45 mg/dL; hyperglycemia as BGL>240 mg/dL in a single determination or >180 m...

Global cerebral ischemia and intracellular pH during hyperglycemia and hypoglycemia in cats.

In 27 cats treated to vary arterial serum glucose concentrations, we measured cerebral high-energy phosphate metabolite concentration and intracellular pH using in vivo phosphorus-31 nuclear magnetic resonance spectroscopy during transient global cerebral ischemia and reperfusion. Hypoglycemia was induced with 4 units/kg i.v. insulin in six cats before ischemia; hyperglycemia was induced with 1...